[Non-inflammatory muscle pain]. / Nichtentzündliche Muskelschmerzen.

Muscle pain as a common symptom in daily practice frequently occurs as a non-specific accompanying symptom in multiple internal and neurological diseases. Primarily inflammatory or autoimmune muscular diseases are causing muscle pain. However, a number of non-inflammatory causes of pain can also be considered for differential diagnosis. These are presented in this article. In principle, a distinction must be made between focal and diffuse muscle pain. As an invasive diagnostic procedure, a muscle biopsy should only be performed as the last step in the diagnostic alogorithm. If diffuse muscle pain is only associated with slight muscle weakness or is completely absent, there is usually a primary rheumatic cause. Statins (HMG-CoA reductase inhibitors) can lead to rhabdomyolysis, muscle fiber atrophy and muscle necrosis by damaging the muscle fiber membrane. Myotonias are autosomal dominant or autosomal recessive inherited disorders of muscle function. The genetic defect leads to pronounced muscle stiffness. The cause of metabolic myopathies can be disorders of the carbohydrate, fat or purine metabolism. Fibromyalgia syndrome (FMS) is a non-inflammatory disease and, according to the current knowledge, recognized as the result of an exposure to physical, biological and psychosocial factors (biopsychological disease model). To help diagnosing FMS, pain regions and core symptoms (fatigue, sleep disturbances) can be detected using questionnaires (Widespread Pain Index [WPI] and Symptom Severity Scale [SSS]).

Short-Term Sensorimotor Effects of Experimental Occlusal Interferences on the Wake-Time Masseter Muscle Activity of Females with Masticatory Muscle Pain.

AIMS: To investigate the effects of the application of an acute alteration of the occlusion (ie, interference) on the habitual masseter electromyographic (EMG) activity of females with temporomandibular disorders (TMD)-related muscular pain during wakefulness. METHODS: Seven female volunteers with masticatory myofascial pain participated in a crossover randomized clinical trial. Gold foils were glued on an occlusal contact area (active occlusal interference, AI) or on the vestibular surface of the same molar (dummy interference, DI) and left for 8 days. The masseter electromyogram was recorded during wakefulness in the natural environment by portable recorders under interference-free, dummy-interference, and active-interference conditions. The number, amplitude, and duration of EMG signal fractions with amplitudes above 10% of the maximum voluntary contraction (activity periods, APs) were computed in all experimental conditions. Muscle pain, headache, and perceived stress were each assessed with a visual analog scale (VAS), and an algometer was used to assess masseter and temporalis pressure pain thresholds. Data were analyzed by means of analysis of variance. RESULTS: The frequency and duration of the recorded APs did not differ significantly between the experimental conditions (P>.05), but a small and significant reduction of the EMG mean amplitude of the APs occurred with AI (P<.05). Neither the VAS scores for muscular pain, headache, and perceived stress nor the pressure pain thresholds changed significantly throughout the entire experiment (P>.05). CONCLUSION: An active occlusal interference in female volunteers with masticatory muscle pain had little influence on the masseter EMG activity pattern during wakefulness and did not affect the pressure tenderness of the masseter and temporalis.

Phenotype standardization for statin-induced myotoxicity.

Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed an algorithm to define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, and necrotizing autoimmune myopathy.

Correlation between bony changes measured with cone beam computed tomography and clinical dysfunction index in patients with temporomandibular joint osteoarthritis.

OBJECTIVES: To investigate the correlation between clinical dysfunction index (Di) and condylar bony changes, glenoid fossa bony changes and joint space changes. METHODS: Clinical data and cone beam computed tomography (CBCT) images of 240 patients with temporomandibular joint osteoarthritis (TMJ OA) were analyzed. The patients were assigned a score of Helkimo's clinical Di ranging from 1 to 25 and thereafter divided into 3 groups by the degree of Helkimo's Di. The condylar bony changes observed with CBCT were graded by the classification method of Koyama et al. Glenoid fossa bony changes and joint space changes were both classified as "positive" or "negative". Spearman's rank correlation test was used to correlate the score or degree of Helkimo's Di with the maximum condylar bony changes, glenoid fossa bony changes, and joint space changes. RESULTS: There was a significant correlation between the Helkimo's Di score and the maximum condylar bony changes (P ≤ 0.0001) and glenoid fossa bony changes (P ≤ 0.0001), and there was a poor correlation between the Helkimo's Di score and joint space changes (P = 0.184). Furthermore, there was a significant correlation between the degree of Helkimo's Di and the maximum condylar bony changes (P ≤ 0.0001) and glenoid fossa bony changes (P ≤ 0.0001), but there was a poor correlation between the degree of Helkimo's Di and joint space changes (P = 0.346). CONCLUSIONS: Both the score and degree of Helkimo's Di were highly correlated with maximum condylar changes and glenoid fossa bony changes, but not with joint space changes.

Eficácia do Shiatsu na dor, sono, ansiedade, nível de confiança no equilibrio e qualidade de vida de indivíduos com fibromialgia: um ensaio clínico controlado / Efficacy of Shiatsu on pain, sleep, anxiety, balance confidence level and quality of life in individuals with fibromyalgia: a controlled clinical trial

Introdução: A fibromialgia é uma desordem reumatológica comum que compromete significativamente a qualidade de vida. Caracteriza-se por dor crônica generalizada e limiar de dor diminuído, associados normalmente a sintomas e comorbidades, como sono não reparador, distúrbios de equilíbrio e ansiedade. Dentre as modalidades de tratamento, vem crescendo o uso das terapias alternativas e complementares, porém mais evidências são necessárias. O objetivo principal deste estudo foi avaliar o efeito do Shiatsu na dor, qualidade de sono, ansiedade, nível de confiança no equilíbrio e qualidade de vida relacionada à saúde de indivíduos com fibromialgia. Método: participaram do estudo 34 sujeitos na faixa etária de 33 a 62 anos, divididos em: Grupo Shiatsu (GS; n=17), que realizou 16 sessões de Shiatsu corporal com duração de 50 minutos, duas vezes por semana, e Grupo Controle (GC; n=17), que recebeu orientações educativas através de uma cartilha. Os grupos foram avaliados na linha de base, após 4 e 8 semanas, quanto a: intensidade da dor pela Escala Visual Analógica (EVA), limiar de dor pela dolorimetria, qualidade de sono pelo Índice de Qualidade de Sono de Pittsburgh (IQSP), ansiedade pelo Inventário de Ansiedade Traço-Estado, confiança no equilíbrio pela Escala de Confiança no Equilíbrio em Atividades Específicas (Escala ABC) e qualidade de vida pelo Questionário de Impacto da Fibromialgia (QIF). Resultados: por regressão logística, verificou-se que o tratamento de oito semanas com Shiatsu está associado à melhora na EVA (p=0,043), limiar de dor (p=0,014), IQSP (p=0,006), Escala ABC (p=0,026) e QIF (p=0,016). Todas essas variáveis também apresentaram ganho percentual relativo clinicamente importante (EVA: 40,6%; limiar de dor: 76,4%; IQSP: 34,4%; Escala ABC: 44,2%; QIF: 22,3%). Não foram observadas melhoras estatisticamente significantes ou clinicamente relevantes para a ansiedade. Conclusão: o Shiatsu foi eficaz para melhorar a dor, qualidade de sono, confiança no equilíbrio e qualidade de vida de sujeitos com fibromialgia.(AU)

Introduction: Fibromyalgia is a common rheumatological disorder that greatly impairs quality of life. It is characterized by chronic widespread pain and decreased pain threshold, normally associated with symptoms and comorbidities, such as non-restorative sleep, balance disorders and anxiety. Among treatment modalities, the use of complementary and alternative therapies is increasing, but more evidence is needed. The main objective of this study was to evaluate the effect of Shiatsu in pain, sleep quality, anxiety, balance confidence level and health-related quality of life of individuals with fibromyalgia. Methods: 34 subjects aged 33 to 62 years participated in this study and were divided into: Shiatsu Group (SG; n=17), which received 16 sessions of full-body Shiatsu lasting 50 minutes, twice a week, and Control Group (CG; n=17), which received educational guidance through a booklet. Groups were assessed at baseline, after 4 and 8 weeks, regarding: pain intensity by Visual Analogue Scale (VAS), pain threshold by dolorimetry, sleep quality by Pittsburgh Sleep Quality Index (PSQI), anxiety by State-Trait Anxiety Inventory, balance confidence level by Activities-specific Balance Confidence Scale (ABC Scale) and quality of life by the Fibromyalgia Impact Questionnaire (FIQ). Results: by logistic regression, it was found that the eight-week treatment with Shiatsu was associated with improvements in VAS (p=0.043), pain threshold (p=0.014), PSQI (p=0.006), ABC Scale (p=0.026) and FIQ (p=0.016). All these variables also presented clinically important relative percentage changes (VAS: 40.6%; pain threshold: 76.4%; PSQI: 34.4%; ABC Scale: 44.2%; FIQ: 22.3%). There were no statistically significant or clinically relevant improvements for anxiety. Conclusion: Shiatsu was effective for improving pain, sleep quality, balance confidence and quality of life of subjects with fibromyalgia.(AU)